TIM-3 Protein

TIM-3 Protein Overview

TIM-3 protein family

Belongs to the immunoglobulin superfamily. TIM family.

TIM-3 protein name

Recommended name
Hepatitis A virus cellular receptor 2
Short name
HAVcr-2||TIMD-3||TIM-3
Aliases
CD366, FLJ14428, T-cell immunoglobulin mucin family member 3, TIM3, Tim-3, TIMD3
Alternative name
T-cell immunoglobulin and mucin domain-containing protein 3 T-cell immunoglobulin mucin receptor 3 T-cell membrane protein 3

TIM-3 Protein Sequence

Species Human TIM-3 protein
Length 301
Mass (Da) 33394
Sequence Human TIM-3 protein sequence
Species Mouse TIM-3 protein
Length 281
Mass (Da) 30934
Sequence Mouse TIM-3 protein sequence
Species Rat TIM-3 protein
Length 282
Mass (Da) 30641
Sequence Rat TIM-3 protein sequence

TIM-3 Protein Molecular Weight & PI

Hepatitis A virus cellular receptor 2 precursor (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 22-301 Hepatitis A virus cellular receptor 2.

Molecular weight (Da)

30967.27

Theoretical pI

5.39

TIM-3 Protein Structure

Human T-cell immunoglobulin and mucin domain protein 3 (hTIM-3)
Deposited
2015-12-07   Released:  2016-02-03
Deposition Author(s)
Gao, G.F., Lu, G., Wang, H., Qi, J.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.4040 Å
R-Value Free
0.257
R-Value Work
0.215
5F71 From PDB

Human TIM-3 protein Secondary structure

TIM-3 Protein Interaction

Recombinant TIM-3 Protein Feature

TIM-3 Protein, Human, Recombinant (His & Fc Tag)

High Purity
> 88 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

Recombinant TIM-3 protein citations

Title
Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3)
Year
2016
Author
Homayouni, V;hakemi, MG;Rezaei, A;Khanahmad, H;Behdani, M;Lomedasht, FK;
Journal
Iranian Journal of Basic Medical Sciences
Title
Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy
Year
2017
Author
Sabatos-Peyton, CA;Nevin, J;Brock, A;Venable, JD;Tan, DJ;Kassam, N;Xu, F;Taraszka, J;Wesemann, L;Pertel, T;Acharya, N;Klapholz, M;Etminan, Y;Jiang, X;Huang, Y;Blumberg, RS;Anderson, VK;
Journal
OncoImmunology
Title
Development of an AlphaLISA Assay for Screening Inhibitors of the TIM-3/Gal-9 Interaction
Year
2017
Author
Cao, H;Carlstrom, J;Hopkinton, MA;
Journal
APPLICATION NOTE
Title
Stimulation of Camel Polyclonal Antibody against Human T cell Immunoglobulin and Mucin 3
Year
2017
Author
Homayouni, V;Khanahmad, H;Ganjalikhani-hakemi, M;Behdani, M;Ghasemi, P;rezaei, a;
Journal
Iranian Journal of Biotechnology

Bulk Order of Recombinant TIM-3 Protein

Please Leave Us a Message if you have any questions regarding bulk price quote of our products on the website, our customer specialist will get back to you in 24 hours by email.

Custom Recombinant Protein Production Service Features

  • Over 10 years' experience for 6000+ recombinant proteins production.
  • One-stop service from gene synthesis and vector construction to protein expression and purification.
  • Multiple protein expression systems: bacterial, yeast, baculovirus-insect and mammalian expression system.
  • Multiple purification systems (30+) to choose.
  • High R & D ability with over 1000 new proteins per year and quick problem-solving ability.
  • Close to 100 bioreactors with various volume between 2-1000 L to guarantee high-throughput and large-scale production.

Custom Recombinant Protein Production Service Advantages

  • High-efficiency expression vectors
  • High cell density culturing
  • Proprietary medium formulation
  • >6000 proteins expression and purification experience
  • High-efficiency expression vectors
  • High cell density culturing

Recombinant Protein Production Service Description

We offer one-stop services for recombinant protein production using our advanced protein expression platform technologies. Our full services include protein gene synthesis, protein codon optimization, protein expression vector design, large scale cell culture and fermentation, protein purification, and protein quality control testing. We offer significant cost saving advantages and record speed in protein expression and bulk production. We also have extensive experiences and expertise in handling various types of recombinant protein purification projects, with or without purification tags.