PD-1 cDNA Clone: Expression and Clone Vector / Plasmid

PD-1 cDNA / Gene Overview

PDCD1 gene / cDNA is a protein-coding gene which located on 2q37.3. The PDCD1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.168 organisms have orthologs with human gene PDCD1.

PD-1 cDNA / Gene Function

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]

PD-1 cDNA / Gene Sequence

LOCUS
LOCUS NM_005018 2115 bp mRNA linear PRI 05-AUG-2018
DEFINITION
Homo sapiens programmed cell death 1 (PDCD1), mRNA.
ACCESSION
NM_005018
VERSION
NM_005018.2

This sequence information is just for reference only.

PD-1 Family & Reagents

PD-1 Gene family reagents (CD molecules)

Approved Symbol Reagent list
CD44
CLEC4D
SIRPA
LILRB5
PDGFRB
CD22
JAG1
TLR2
LAMP3
FCAR
Approved Symbol Reagent list
CSF2RB
CD14
FGFR3
TREM1
FCGR3B
CD83
ICOSLG
CDH2
TNFRSF18
FCRL2

PD-1 Gene family reagents (V-set domain containing)

Approved Symbol Reagent list
ICOSLG
CD80
TIMD4
PVR
PIGR
NCR3
CD79B
Vsir
VTCN1
ESAM
Approved Symbol Reagent list
CD300A
SCN2B
CD2
CEACAM19
CD276
CD300LG
NECTIN2
MOG
KDR
TREM1

PD-1 cDNA / Gene Alias

  • CD279
  • hSLE1
  • PD1
  • PD-1

PD-1 cDNA / Gene Expression

Biased expression in lymph node (RPKM 8.8), spleen (RPKM 2.6) and 7 other tissues

Recombinant PD-1 protein citations

Title
Enhancement of SIV-specific cell mediated immune responses by co-administration of soluble PD-1 and Tim-3 as molecular adjuvants in mice
Year
2014
Author
Lijun Xiao1,2, Dimin Wang3, Pingchao Li1, Yi Jin1,2, Liqiang Feng1*, Caijun Sun1*, and Ling Chen
Journal
Human Vaccines & Immunotherapeutics
Title
Non-conventional Inhibitory CD4+Foxp3-PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity
Year
2018
Author
Zappasodi, R;Budhu, S;Hellmann, MD;Postow, MA;Senbabaoglu, Y;Manne, S;Gasmi, B;Liu, C;Zhong, H;Li, Y;Huang, AC;Hirschhorn-Cymerman, D;Panageas, KS;Wherry, EJ;Merghoub, T;Wolchok, JD;
Journal
Cancer Cell