IkB alpha cDNA Clone: Expression and Clone Vector / Plasmid

IkB alpha cDNA / Gene Overview

NFKBIA gene / cDNA is a protein-coding gene which located on 14q13.2. The NFKBIA gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.230 organisms have orthologs with human gene NFKBIA.

IkB alpha cDNA / Gene Function

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]

IkB alpha cDNA / Gene Sequence

LOCUS
LOCUS NM_020529 1579 bp mRNA linear PRI 22-JUL-2018
DEFINITION
Homo sapiens NFKB inhibitor alpha (NFKBIA), mRNA.
ACCESSION
NM_020529
VERSION
NM_020529.2

This sequence information is just for reference only.

IkB alpha Family & Reagents

IkB alpha Gene family reagents (Ankyrin repeat domain containing)

Approved Symbol Reagent list
ACBD6
DAPK1
NOTCH2
Approved Symbol Reagent list
CDKN2D
NOTCH1
NOTCH4

IkB alpha cDNA / Gene Alias

  • IkappaBalpha
  • IKBA
  • MAD-3
  • NF-kappa-B inhibitor alpha

IkB alpha cDNA / Gene Expression

Broad expression in bone marrow (RPKM 430.4), ovary (RPKM 112.0) and 21 other tissues