DDR1 cDNA Clone: Expression and Clone Vector / Plasmid
DDR1 cDNA / Gene Overview
DDR1 gene / cDNA is a protein-coding gene which located on 6p21.33. The DDR1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog.165 organisms have orthologs with human gene DDR1.
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
DDR1 cDNA / Gene Sequence
LOCUS NM_013994 3678 bp mRNA linear PRI 29-JUL-2018
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