BCL6 (Protein | Antibody | cDNA Clone | ELISA Kit)

All BCL6 reagents are produced in house and quality controlled, including 2 BCL6 Antibody, 15 BCL6 Gene, 1 BCL6 Protein, 1 BCL6 qPCR. All BCL6 reagents are ready to use.

BCL6 Protein (1)

    BCL6 Antibody (2)

      BCL6 cDNA Clone (15)

      BCL6 qPCR Primer (1)

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      BCL6 Background

      The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin's lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein.

      BCL6 References

      • Ye BH, et al. (1997) The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nature Genetics. 16: 161-70.
      • Seyfert VL, et al. (1996) Transcriptional repression by the proto-oncogene BCL-6. Oncogene. 12 (11) : 2331-42.
      • Chang CC, et al. (1996) BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. PNAS. 93 (14): 6947-52.