Transferrin Receptor / TFRC Protein, Mouse, Recombinant (His Tag)

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Transferrin Receptor / TFRC Protein, Mouse, Recombinant (His Tag): Product Information

Purity
> 92 % as determined by SDS-PAGE
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the extracellular domain of mouse TFRC (Q62351) (Cys 89-Phe 763) was fused with a polyhistidine tag at the N-terminus.
Accession#
Expressed Host
HEK293 Cells
Species
Mouse
Predicted N Terminal
His
Molecule Mass
The recombinant mouse TFRC comprises 694 amino acids and predicts a molecular mass of 78.3 kDa. The apparent molecular mass of mouse TFRC is approximately 80 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Transferrin Receptor / TFRC Protein, Mouse, Recombinant (His Tag): Images

Transferrin Receptor / TFRC Protein, Mouse, Recombinant (His Tag): Alternative Names

2610028K12Rik Protein, Mouse; AI195355 Protein, Mouse; AI426448 Protein, Mouse; AU015758 Protein, Mouse; CD71 Protein, Mouse; E430033M20Rik Protein, Mouse; Mtvr-1 Protein, Mouse; Mtvr1 Protein, Mouse; p90 Protein, Mouse; TFR Protein, Mouse; TFR1 Protein, Mouse; TR Protein, Mouse; Trfr Protein, Mouse

Transferrin Receptor / TFRC Background Information

Transferrin receptor protein 1, also known as transferrin receptor, Trfr, p9, CD71 and TFRC, is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily. TFRC / CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a diagnostic tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC / CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC / CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential diagnostic and therapeutic target.
Full Name
transferrin receptor
References
  • Douabin-Gicquel V., et al., 2001,Hum. Genet. 109:393-401.
  • Ryschich,E. et al., 2004,Eur J Cancer. 40 (9):1418-22.
  • Tosoni D., et al., 2005, Cell 123:875-888.
  • Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
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    Author
    Salvati, E;Re, F;Sesana, S;Cambianica, I;Sancini, G;Masserini, M;Gregori, M;
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    Author
    Boado, RJ;Lu, JZ;Hui, EK;Pardridge, WM;
    Year
    2017
    Journal
    Mol. Pharm.
    Application
    ELISA
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