Transferrin Protein

Transferrin Protein Overview

Transferrin protein family

Belongs to the transferrin family.

Transferrin protein name

Recommended name
Serotransferrin
Short name
Transferrin
Aliases
PRO1557, PRO2086, serotransferrin
Alternative name
Beta-1 metal-binding globulin Siderophilin

Transferrin Gene family protein

Transferrins

Transferrin Protein Sequence

Species Human Transferrin protein
Length 698
Mass (Da) 77064
Sequence Human Transferrin protein sequence
Species Mouse Transferrin protein
Length 697
Mass (Da) 76724
Sequence Mouse Transferrin protein sequence
Species Rat Transferrin protein
Length 698
Mass (Da) 76395
Sequence Rat Transferrin protein sequence

Transferrin Protein Molecular Weight & PI

Serotransferrin precursor (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 20-698 Serotransferrin.

Molecular weight (Da)

75195.46

Theoretical pI

6.70

Transferrin Protein Structure

Crystal structure of K206E/K296E mutant of the N-terminal half molecule of human transferrin
Deposited
2006-12-11   Released:  2007-01-23
Deposition Author(s)
Baker, H.M., Nurizzo, D., Mason, A.B., Baker, E.N.
Organism(s)
Homo sapiens
Expression System
Mesocricetus auratus
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.8000 Å
R-Value Free
0.259
R-Value Work
0.230
2O7U From PDB

Human Transferrin protein Secondary structure

Transferrin Protein Interaction

Recombinant Transferrin Protein Feature

Transferrin Protein, Human, Recombinant (His Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
1. Measured by its binding ability in a functional ELISA. Immobilized human CD71 at 10 μg/ml (100 μl/well) can bind human Transferrin. The EC50 of human Transferrin is 5.6 ng/mL. 2. Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. The ED50 for this effect is typically 0.01-0.04 μg/mL.

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