TNFRSF1A Protein

TNFRSF1A Protein Overview

TNFRSF1A protein name

Recommended name
Tumor necrosis factor receptor superfamily member 1A
Aliases
CD120a, TNFAR, TNF-R, TNF-R55, TNFR60, TNF-R-I
Alternative name
Tumor necrosis factor receptor 1 Tumor necrosis factor receptor type I p55 p60 CD_antigen: CD120a Tumor necrosis factor receptor superfamily member 1A, membrane form Tumor necrosis factor-binding protein 1

TNFRSF1A Gene family protein

TNFRSF1A Protein Sequence

Species Human TNFRSF1A protein
Length 455
Mass (Da) 50495
Sequence Human TNFRSF1A protein sequence
Species Mouse TNFRSF1A protein
Length 454
Mass (Da) 50130
Sequence Mouse TNFRSF1A protein sequence
Species Rat TNFRSF1A protein
Length 461
Mass (Da) 50969
Sequence Rat TNFRSF1A protein sequence

TNFRSF1A Protein Molecular Weight & PI

Tumor necrosis factor receptor superfamily member 1A precursor (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD120a antigen) [Contains: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)] Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 30-455 Tumor necrosis factor receptor

Molecular weight (Da)

47520.19

Theoretical pI

6.59

TNFRSF1A Protein Structure

EXTRACELLULAR DOMAIN OF THE 55KDA TUMOR NECROSIS FACTOR RECEPTOR. CRYSTALLIZED AT PH3.7 IN P 21 21 21.
Deposited
1996-07-03   Released:  1997-01-11
Deposition Author(s)
Naismith, J.H., Sprang, S.R.
Organism(s)
Homo sapiens
Expression System
Escherichia coli
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
1.8500 Å
R-Value Free
0.243
R-Value Work
0.203
1EXT From PDB

Human TNFRSF1A protein Secondary structure

TNFRSF1A Protein Interaction

Recombinant TNFRSF1A Protein Feature

TNFRSF1A Protein, Human, Recombinant (His Tag)

High Purity
> 92 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
1. Measured by its binding ability in a functional ELISA. Immobilized human TNFRI-His at 10 μg/mL (100 μl/well) can bind biotinylated human TNFα. The EC50 of biotinylated human TNFα is 5-12 μg/mL. 2. Measured by its ability to inhibit TNFα-mediated cytotoxicity in L929 mouse fibrosarcoma cells in the presence of metabolic inhibitor actinomycin D. The ED50 for this effect is typically 0.2-1μg/mL in the presence of 0.25 ng/mL recombinant human TNFα.

Recombinant TNFRSF1A protein citations

Title
Novel human three-domain antibody fragments against sTNFα as well as tmTNFα with high affinity generated by the combination of ribosome display and E.coli expression system
Year
2016
Author
Zhao, XL;Tian, LF;Zhang, SJ;Li, JM;Feng, H;Wang, LM;Wang, S;Wang, J;Wang, T;Chen, WQ;
Journal
Scand. J. Immunol.
Title
Sertraline ameliorates inflammation in CUMS mice and inhibits TNF-α-induced inflammation in microglia cells
Year
2018
Author
Lu, Y;Xu, X;Jiang, T;Jin, L;Zhao, XD;Cheng, JH;Jin, XJ;Ma, J;Piao, HN;Piao, LX;
Journal
Int. Immunopharmacol.

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