TNFRSF1A cDNA Clone: Expression and Clone Vector / Plasmid

TNFRSF1A cDNA / Gene Overview

TNFRSF1A gene / cDNA is a protein-coding gene which located on 12p13.31. The TNFRSF1A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.184 organisms have orthologs with human gene TNFRSF1A.

TNFRSF1A cDNA / Gene Function

This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]

TNFRSF1A cDNA / Gene Sequence

LOCUS
LOCUS NM_001065 2258 bp mRNA linear PRI 12-AUG-2018
DEFINITION
Homo sapiens TNF receptor superfamily member 1A (TNFRSF1A), transcript variant 1, mRNA.
ACCESSION
NM_001065
VERSION
NM_001065.3

This sequence information is just for reference only.

TNFRSF1A Family & Reagents

TNFRSF1A Gene family reagents (CD molecules)

Approved Symbol Reagent list
LAMP2
TNFSF11
CD28
CD81
CD2
TNFRSF8
IFNGR1
CEACAM1
SIRPA
NECTIN3
Approved Symbol Reagent list
IL7R
CD244
SIRPG
CD52
TNFRSF10D
CD276
PDGFRB
CD55
TNFRSF18
FCRL2

TNFRSF1A Gene family reagents (Tumor necrosis factor receptor superfamily)

Approved Symbol Reagent list
TNFRSF25
TNFRSF19
TNFRSF6B
RELT
TNFRSF4
NGFR
TNFRSF10B
TNFRSF11B
CD40
TNFRSF13B
Approved Symbol Reagent list
TNFRSF11A
LTBR
TNFRSF8
EDA2R
TNFRSF1B
EDAR
TNFRSF21
TNFRSF18
TNFRSF10D
TNFRSF13C

TNFRSF1A cDNA / Gene Alias

  • CD120a
  • TNFAR
  • TNF-R
  • TNF-R55
  • TNFR60
  • TNF-R-I

TNFRSF1A cDNA / Gene Expression

Ubiquitous expression in small intestine (RPKM 52.0), gall bladder (RPKM 48.9) and 25 other tissues