TNFRSF1A: TNFRSF1A Protein | TNFRSF1A Antibody

TNFRSF1A Gene family

TNFRSF1A Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD120a (cluste of differentiation 120a), also known as TNFR1 / TNFRSF1A, is a member of CD family, tumor necrosis factor receptor superfamily. CD120a is one of the most primary receptors for the tumor necrosis factor-alpha. It has been shown to be localized to both plasma membrane lipid rafts and the trans golgi complex with the help of the death domain (DD). CD120a can activate the transcription factor NF-κB, mediate apoptosis, and regulate inflammation processes.

TNFRSF1A Protein

TNFRSF1A protein function

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

TNFRSF1A protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    455.00
  • Mass (Da)
    50.00

TNFRSF1A Antibody

There are 18 TNFRSF1A antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Det), ELISA(Cap), ICC/IF, Neutralization, WB, IHC-P. There are 12 TNFRSF1A antibody for ELISA, 2 TNFRSF1A antibody for ELISA(Det), 2 TNFRSF1A antibody for ELISA(Cap), 1 TNFRSF1A antibody for ICC/IF, 1 TNFRSF1A antibody for Neutralization, 2 TNFRSF1A antibody for WB, 1 TNFRSF1A antibody for IHC-P. Among all these TNFRSF1A antibodies, there are 4 anti-TNFRSF1A mouse monoclonal antibodies , 6 anti-TNFRSF1A rabbit monoclonal antibodies , 8 anti-TNFRSF1A rabbit polyclonal antibodies . All the TNFRSF1A anbodies are produced in house and all are in stock. TNFRSF1A antibody customerized service is available.

TNFRSF1A Gene

TNFRSF1A gene / cDNA is a protein-coding gene which located on 12p13.31. The TNFRSF1A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.184 organisms have orthologs with human gene TNFRSF1A.