RANK / TNFRSF11A: RANK / TNFRSF11A Protein | RANK / TNFRSF11A Antibody

RANK / TNFRSF11A Gene family

RANK / TNFRSF11A Background

TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. Defects in TNFRSF11A can cause familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.

Reference for RANK / TNFRSF11A

  • Darnay B G, et al. (1998) Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase. J Biol Chem. 273(32):20551-5.
  • Darnay B G, et al. (1999) Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. J Biol Chem. 274(12):7724-31.
  • Galibert L, et al. (1998) The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J Biol Chem. 273(51):34120-7.

RANK / TNFRSF11A Protein

RANK / TNFRSF11A protein function

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. {ECO:0000269|PubMed:9878548}.

RANK / TNFRSF11A protein expression

Tissue specificity

Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

RANK / TNFRSF11A protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    616.00
  • Mass (Da)
    66.00

RANK / TNFRSF11A Antibody

There are 8 RANK / TNFRSF11A antibodies which are validated in multiple tissues with various applications, including WB, ICC/IF, ELISA. There are 2 RANK / TNFRSF11A antibody for WB, 1 RANK / TNFRSF11A antibody for ICC/IF, 7 RANK / TNFRSF11A antibody for ELISA. Among all these RANK / TNFRSF11A antibodies, there are 6 anti-RANK / TNFRSF11A rabbit polyclonal antibodies , 2 anti-RANK / TNFRSF11A rabbit monoclonal antibodies . All the RANK / TNFRSF11A anbodies are produced in house and all are in stock. RANK / TNFRSF11A antibody customerized service is available.

RANK / TNFRSF11A Gene

TNFRSF11A gene / cDNA is a protein-coding gene which located on 18q21.33. The TNFRSF11A gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and frog.215 organisms have orthologs with human gene TNFRSF11A.