TLR4 Protein

TLR4 Protein Sequence

Species Human TLR4 protein
Length 839
Mass (Da) 95680
Sequence Human TLR4 protein sequence
Species Mouse TLR4 protein
Length 835
Mass (Da) 95519
Sequence Mouse TLR4 protein sequence
Species Rat TLR4 protein
Length 835
Mass (Da) 96072
Sequence Rat TLR4 protein sequence

TLR4 Protein Molecular Weight & PI

Toll-like receptor 4 precursor (hToll) (CD284 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 24-839 Toll-like receptor 4.

Molecular weight (Da)

93274.15

Theoretical pI

5.78

TLR4 Protein Structure

Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61
Deposited
2007-07-22   Released:  2007-09-18
Deposition Author(s)
Lee, J.-O., Kim, H.M., Park, B.S.
Organism(s)
Homo sapiens, Eptatretus burgeri
Expression System
Spodoptera frugiperda
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
1.9000 Å
R-Value Free
0.219
R-Value Work
0.209
2Z66 From PDB

Human TLR4 protein Secondary structure

TLR4 Protein Interaction

Recombinant TLR4 Protein Feature

TLR4 Protein, Human, Recombinant (His Tag)

High Purity
> 87 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

Recombinant TLR4 protein citations

Title
Catalpol restores LPS-elicited rat microcirculation disorder by regulation of a network of signaling involving inhibition of TLR-4 and Src
Year
2016
Author
Zhang, YP;Pan, CS;Yan, L;Liu, YY;Hu, BH;Chang, X;Li, Q;Huang, DD;Sun, HY;Fu, G;Sun, K;Fan, JY;Han, JY;
Journal
Am. J. Physiol. Gastrointest. Liver Physiol.
Title
Cellular uptake of exogenous calcineurin B is dependent on TLR4/MD2/CD14 complexes, and CnB is an endogenous ligand of TLR4
Year
2016
Author
Yang, J;Qin, N;Zhang, H;Yang, R;Xiang, B;Wei, Q;
Journal
Sci Rep
Title
Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke
Year
2017
Author
Takamiya, R;Uchida, K;Shibata, T;Maeno, T;Kato, M;Yamaguchi, Y;Ariki, S;Hasegawa, Y;Saito, A;Miwa, S;Takahashi, H;Akaike, T;Kuroki, Y;Takahashi, M;
Journal
Sci Rep
Title
A β-glucan from Durvillaea Antarctica has immunomodulatory effects on RAW264.7 macrophages via toll-like receptor 4
Year
2018
Author
Yang, Y;Zhao, X;Li, J;Jiang, H;Shan, X;Wang, Y;Ma, W;Hao, J;Yu, G;
Journal
Carbohydr Polym

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