Thrombomodulin: Thrombomodulin Protein | Thrombomodulin Antibody

Thrombomodulin Gene family

Thrombomodulin Background

Thrombomodulin, also known as THBD(CD141), is an integral membrane protein which reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. Thrombomodulin is expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It is also expressed on human mesothelial cell, monocyte and a dendritic cell subset. Thrombomodulin functions as a cofactor in the thrombin-induced activation of protein C in the anticoagulant pathway by forming a 1:1 stoichiometric complex with thrombin. Thrombomodulin also regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene have also been reported to be associated with atypical hemolytic-uremic syndrome.

Reference for Thrombomodulin

  • Dzionek A, et al. (2002) Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions. Hum Immunol. 63(12):1133-48.
  • Dzionek A, et al. (2000) BDCA-2, BDCA-3, and BDCA-4: three markers for distinct subsets of dendritic cells in human peripheral blood. J Immunol. 165(11):6037-46.
  • Wen DZ, et al. (1987) Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene. Biochemistry. 26(14):4350-7.

Thrombomodulin Protein

Thrombomodulin protein function

Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

Thrombomodulin protein expression

Tissue specificity

Endothelial cells are unique in synthesizing thrombomodulin.

Thrombomodulin protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

Thrombomodulin Antibody

There are 5 Thrombomodulin antibodies which are validated in multiple tissues with various applications, including IHC-P, ELISA. There are 3 Thrombomodulin antibody for IHC-P, 3 Thrombomodulin antibody for ELISA. Among all these Thrombomodulin antibodies, there are 3 anti-Thrombomodulin rabbit polyclonal antibodies , 2 anti-Thrombomodulin rabbit monoclonal antibodies . All the Thrombomodulin anbodies are produced in house and all are in stock. Thrombomodulin antibody customerized service is available.

Thrombomodulin Gene

THBD gene / cDNA is a protein-coding gene which located on 20p11.21. The THBD gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.155 organisms have orthologs with human gene THBD.