SUV39H1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All SUV39H1 reagents are produced in house and quality controlled, including 1 SUV39H1 Antibody, 31 SUV39H1 Gene, 1 SUV39H1 qPCR. All SUV39H1 reagents are ready to use.

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SUV39H1 Related Research Area

SUV39H1 Background

SUV39H1, the histone methyltransferase (HMTase) of histone H3 lysine 9 trimethylation (H3K9me3), is a known transcriptional repressor of inflammatory genes. SUV39H1 as an oncogene in melanoma and underscore the role of chromatin factors in regulating tumorigenesis. The ability of mycobacteria to form biofilms, a survival strategy of the bacteria dependent upon cell-cell adhesion, was dramatically reduced in the presence of SUV39H1. Thus, this novel defense mechanism against mycobacteria represents a surrogate function of the epigenetic modulator, SUV39H1, and operates by interfering with their cell-cell adhesion ability. Overexpression of SUV39H1 may reduce renal inflammation and apoptosis via epigenetic modulation, thus plays a protective role in DN.