SIGLEC6: SIGLEC6 Protein | SIGLEC6 Antibody

SIGLEC6 Gene family

SIGLEC6 Background

SIGLEC6, also known as CD327, belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family. SIGLEC6 is a sialic acid recognizing protein expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. SIGLEC6 localizes in various compartments such as membrane fraction, extracellular region and so on. SIGLEC6 may show increasing expression human labor and following childbirth, it has been speculated that this expression helps to slow the tempo of human labor.  Interestingly, expression of SIGLEC6 is further upregulated in pre-eclampsia, which appears to be a uniquely human disease.

Reference for SIGLEC6

  • Winn VD. et al., 2009, Endocrinology. 150 (1): 452-62.
  • Davila S. et al., 2010, Genes Immun. 11 (3): 232-8.
  • Lam KK. et al., 2011, J Biol Chem. 286 (43): 37118-27.

SIGLEC6 Protein

SIGLEC6 protein function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

SIGLEC6 protein expression

Tissue specificity

Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.

SIGLEC6 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    453.00
  • Mass (Da)
    49.00

SIGLEC6 Antibody

There are 1 SIGLEC6 antibodies which are validated in multiple tissues with various applications, including WB, IHC-P. There are 1 SIGLEC6 antibody for WB, 1 SIGLEC6 antibody for IHC-P. Among all these SIGLEC6 antibodies, there are 1 anti-SIGLEC6 rabbit polyclonal antibodies . All the SIGLEC6 anbodies are produced in house and all are in stock. SIGLEC6 antibody customerized service is available.

SIGLEC6 Gene

SIGLEC6 gene / cDNA is a protein-coding gene which located on 19q13.41. 16 organisms have orthologs with human gene SIGLEC6.