NKp46/NCR1: NKp46/NCR1 Protein | NKp46/NCR1 Antibody

NKp46/NCR1 Gene family

NKp46/NCR1 Background

NCR1, also known as NK-p46 and CD335, is a natural cytotoxicity receptor(NCR). NCRs are type I transmembrane proteins with 1-2 extracellular immunoglobulin domains, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmic tail. All are expressed almost exclusively by NK cells and play a major role in triggering NK-mediated killing of most tumor cell lines. NKp46 has two extracellular Ig-like domains followed by a ~4 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells, pathogen-infected cell lines and mononuclear phagocytes infected with an intracellular bacterium.

Reference for NKp46/NCR1

  • Carbone E, et al. (2005) HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells. Blood. 105(1):251-8.
  • Sivori S, et al. (1997) p46, a Novel Natural Killer Cell-specific Surface Molecule That Mediates Cell Activation. J Exp Med. 186(7):1129-36.
  • Biassoni R, et al. (2004) Human natural killer cell receptors: insights into their molecular function and structure. J Cell Mol Med. 7(4):376-87.

NKp46/NCR1 Protein

NKp46/NCR1 protein function

Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. {ECO:0000269|PubMed:9730896}.

NKp46/NCR1 protein expression

Tissue specificity

Selectively expressed by both resting and activated NK cells.

NKp46/NCR1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

NKp46/NCR1 Antibody

There are 2 NKp46/NCR1 antibodies which are validated in multiple tissues with various applications, including WB, IP. There are 2 NKp46/NCR1 antibody for WB, 2 NKp46/NCR1 antibody for IP. Among all these NKp46/NCR1 antibodies, there are 2 anti-NKp46/NCR1 rabbit polyclonal antibodies . All the NKp46/NCR1 anbodies are produced in house and all are in stock. NKp46/NCR1 antibody customerized service is available.

NKp46/NCR1 Gene

NCR1 gene / cDNA is a protein-coding gene which located on 19q13.42. The NCR1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.57 organisms have orthologs with human gene NCR1.