LAG3: LAG3 Protein | LAG3 Antibody

LAG3 Gene family

LAG3 Background

LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.

Reference for LAG3

  • Sigrid Hannier. et al., 1998, The Journal of Immunology. 161(8): 4058-65.
  • Triebel F. et al., 1990, J Exp Med. 171 (5): 1393-405.
  • Baixeras E. et al., 1992, J Exp Med. 176 (2): 327-37.
  • Huard B. et al., 1997, Proc Natl Acad Sci. 94 (11): 5744-9.
  • Kisielow M. et al., 2005, Eur J Immunol. 35 (7): 2081-8.

LAG3 Protein

LAG3 protein function

Involved in lymphocyte activation. Binds to HLA class-II antigens.

LAG3 protein expression

Tissue specificity

On cell surface of activated NK and T-lymphocytes.

LAG3 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

LAG3 Antibody

There are 1 LAG3 antibodies which are validated in multiple tissues with various applications, including ELISA. There are 1 LAG3 antibody for ELISA. Among all these LAG3 antibodies, there are 1 anti-LAG3 rabbit polyclonal antibodies . All the LAG3 anbodies are produced in house and all are in stock. LAG3 antibody customerized service is available.

LAG3 Gene

LAG3 gene / cDNA is a protein-coding gene which located on 12p13.31. The LAG3 gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, chicken, and frog.198 organisms have orthologs with human gene LAG3.