KIRREL: KIRREL Protein | KIRREL Antibody

KIRREL Gene family

KIRREL Background

NEPH1 (KIRREL1) belongs to a family of three closely related transmembrane proteins of the Ig superfamily with a structure similar to that of nephrin. All three Neph proteins share a conserved podocin-binding motif; mutation of a centrally located tyrosine residue dramatically lowers the affinity of Neph1 for podocin. Neph1 triggers AP-1 activation similarly to nephrin but requires the presence of Tec family kinases for efficient transactivation. Neph1 consists of a signal peptide, five Ig-like C2-type domains with the middle domain overlapping with a PKD-like domain, an RGD sequence, a transmembrane domain and a cytoplasmic tail, which is expressed in slit diaphragm domains of podocytes and in vertebrate and invertebrate nervous systems. Neph1 is abundantly expressed in the kidney, specifically expressed in podocytes of kidney glomeruli, and plays a significant role in the normal development and function of the glomerular permeability. Neph1 interacts with nephrin in vitro and in vivo, and able to stimulate transcriptional activation in a model system, such as the activation the transcription factor AP-1 via the stimulation of a MAPK module. Neph1 is crucial for the integrity of the slit diaphragm, as Neph1 gene knockout mice results in effacement of glomerular podocytes, heavy proteinuria, and early postnatal death.

Reference for KIRREL

  • Sellin L, et al. (2003) NEPH1 defines a novel family of podocin interacting proteins. FASEB J. 17(1): 115-7.
  • Kim EY, et al. (2009) Neph1 regulates steady-state surface expression of Slo1 Ca(2+)-activated K(+) channels: different effects in embryonic neurons and podocytes. Am J Physiol Cell Physiol. 297(6): C1379-88.

KIRREL Protein

KIRREL protein function

Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250}.

KIRREL protein expression

Tissue specificity

Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.

KIRREL protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    757.00
  • Mass (Da)
    83.00

KIRREL Antibody

There are 1 KIRREL antibodies which are validated in multiple tissues with various applications, including ELISA. There are 1 KIRREL antibody for ELISA. Among all these KIRREL antibodies, there are 1 anti-KIRREL rabbit polyclonal antibodies . All the KIRREL anbodies are produced in house and all are in stock. KIRREL antibody customerized service is available.

KIRREL Gene

KIRREL1 gene / cDNA is a protein-coding gene which located on 1q23.1. The KIRREL1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog.163 organisms have orthologs with human gene KIRREL1.