JAM-A/Junctional Adhesion Molecule A: JAM-A/Junctional Adhesion Molecule A Protein | JAM-A/Junctional Adhesion Molecule A Antibody

JAM-A/Junctional Adhesion Molecule A Gene family

JAM-A/Junctional Adhesion Molecule A Background

Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer.

Reference for JAM-A/Junctional Adhesion Molecule A

  • Guglielmi KM, et al. (2007) Reovirus binding determinants in junctional adhesion molecule-A. J Biol Chem. 282(24): 17930-40.
  • Yeung D, et al. (2008) Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown. Acta Neuropathol. 115(6): 635-42.
  • Ong KL, et al. (2009) Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) in hypertension. Am J Hypertens. 22(5): 500-5.

JAM-A/Junctional Adhesion Molecule A Protein

JAM-A/Junctional Adhesion Molecule A protein function

Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840). {ECO:0000250|UniProtKB:O88792, ECO:0000269|PubMed:10753840, ECO:0000269|PubMed:11489913, ECO:0000269|PubMed:11812992}.; (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1. {ECO:0000269|PubMed:11239401}.; (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. {ECO:0000269|PubMed:25481868}.

JAM-A/Junctional Adhesion Molecule A protein expression

Tissue specificity

Expressed in endothelium, epithelium and leukocytes (at protein level).

JAM-A/Junctional Adhesion Molecule A protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    299.00
  • Mass (Da)
    32.00

JAM-A/Junctional Adhesion Molecule A Antibody

There are 10 JAM-A/Junctional Adhesion Molecule A antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Det), FCM, ICC/IF, ELISA(Cap), WB, IP, IHC-P. There are 4 JAM-A/Junctional Adhesion Molecule A antibody for ELISA, 1 JAM-A/Junctional Adhesion Molecule A antibody for ELISA(Det), 4 JAM-A/Junctional Adhesion Molecule A antibody for FCM, 1 JAM-A/Junctional Adhesion Molecule A antibody for ICC/IF, 1 JAM-A/Junctional Adhesion Molecule A antibody for ELISA(Cap), 1 JAM-A/Junctional Adhesion Molecule A antibody for WB, 1 JAM-A/Junctional Adhesion Molecule A antibody for IP, 1 JAM-A/Junctional Adhesion Molecule A antibody for IHC-P. Among all these JAM-A/Junctional Adhesion Molecule A antibodies, there are 6 anti-JAM-A/Junctional Adhesion Molecule A mouse monoclonal antibodies , 4 anti-JAM-A/Junctional Adhesion Molecule A rabbit polyclonal antibodies . All the JAM-A/Junctional Adhesion Molecule A anbodies are produced in house and all are in stock. JAM-A/Junctional Adhesion Molecule A antibody customerized service is available.

JAM-A/Junctional Adhesion Molecule A Gene

F11R gene / cDNA is a protein-coding gene which located on 1q23.3. The F11R gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish.145 organisms have orthologs with human gene F11R.