ICAM-1: ICAM-1 Protein | ICAM-1 Antibody

ICAM-1 Gene family

ICAM-1 Background

Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 9 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for a number of immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity.

Reference for ICAM-1

  • Xu H, et al. (2001) The role of ICAM-1 molecule in the migration of Langerhans cells in the skin and regional lymph node. Eur J Immunol. 31(10): 3085-93.
  • Terol MJ, et al. (2003) Soluble intercellular adhesion molecule-1 (s-ICAM-1/s-CD54) in diffuse large B-cell lymphoma: association with clinical characteristics and outcome. Ann Oncol. 14(3): 467-74.
  • Mendez MP, et al. (2006) Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 290(5): L962-70.
  • Lawson C, et al. (2009) ICAM-1 signaling in endothelial cells. Pharmacol Rep. 61(1): 22-32.

ICAM-1 Protein

ICAM-1 protein function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:17875742}.; (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. {ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243}.; (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:9539703}.; (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. {ECO:0000269|PubMed:11413168}.

ICAM-1 protein sequence

This sequence information is just for reference only.From Uniport

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ICAM-1 Antibody

There are 31 ICAM-1 antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Cap), FCM, ICC/IF, IHC-P, WB, IP, ELISA(Det). There are 15 ICAM-1 antibody for ELISA, 3 ICAM-1 antibody for ELISA(Cap), 12 ICAM-1 antibody for FCM, 5 ICAM-1 antibody for ICC/IF, 10 ICAM-1 antibody for IHC-P, 2 ICAM-1 antibody for WB, 3 ICAM-1 antibody for IP, 2 ICAM-1 antibody for ELISA(Det). Among all these ICAM-1 antibodies, there are 8 anti-ICAM-1 mouse monoclonal antibodies , 14 anti-ICAM-1 rabbit monoclonal antibodies , 9 anti-ICAM-1 rabbit polyclonal antibodies . All the ICAM-1 anbodies are produced in house and all are in stock. ICAM-1 antibody customerized service is available.

ICAM-1 Gene

ICAM1 gene / cDNA is a protein-coding gene which located on 19p13.2. The ICAM1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat.117 organisms have orthologs with human gene ICAM1.