CNTFR: CNTFR Protein | CNTFR Antibody

CNTFR Gene family

CNTFR Background

Ciliary neurotrophic factor(CNTF) is a member of the cytokine family. It is a polypeptide hormone that have functions in promoting neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. It's actions appear to be restricted to the nervous system. Ciliary neurotrophic factor(CNTF) has biological effects through the activation of a multi-subunit receptor complex, consisting of an extracelluar CNTF binding subunit(CNTFα) and two transmembrane signal transduction proteins: glycoprotein gp13 and LIF receptor. CNTF is considered as a potent survival factor of neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. CNTF is also a survival factor for neurons of the peripheral sensory sympathetic, and ciliary ganglia. It has been reported that CNTF could be an agent that has therapeutic potential and possibly induces differentiation of large multipolar ganglionic phenotype in a subset of progenitors.

Reference for CNTFR

  • Dutt K, et al. (2010) Ciliary neurotrophic factor: a survival and differentiation inducer in human retinal progenitors. In Vitro Cell Dev Biol Anim. 46 (7) : 635-46.
  • Lam A, et al. ( 1991) Sequence and structural organization of the human gene encoding ciliary neurotrophic factor. Gene 102 (2) : 271-6.
  • Bazan JF. ( 1991) Neuropoietic cytokines in the hematopoietic fold. Neuron 7 (2) : 197-208.

CNTFR Protein

CNTFR protein function

Binds to CNTF. The alpha subunit provides the receptor specificity.

CNTFR protein expression

Tissue specificity

Nervous system and skeletal muscle.

CNTFR protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    372.00
  • Mass (Da)
    40.00

CNTFR Antibody

There are 4 CNTFR antibodies which are validated in multiple tissues with various applications, including ELISA. There are 4 CNTFR antibody for ELISA. Among all these CNTFR antibodies, there are 3 anti-CNTFR rabbit polyclonal antibodies , 1 anti-CNTFR mouse monoclonal antibodies . All the CNTFR anbodies are produced in house and all are in stock. CNTFR antibody customerized service is available.

CNTFR Gene

CNTFR gene / cDNA is a protein-coding gene which located on 9p13.3. The CNTFR gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.205 organisms have orthologs with human gene CNTFR.