CHL1: CHL1 Protein | CHL1 Antibody

CHL1 Gene family

CHL1 Background

Neural cell adhesion molecule L1-like protein, also known as close homolog of L1 (CHL1) is the prototypic member of the CTF / NF-1 family of transcription factors that serve as a novel calcium signaling pathway-responsive transcription factor and is considered as a member of the largest ctf complementation group, consisting of 3 of 126 ctf mutants isolated. CHL1 is a cell adhesion molecule highly related to L1. It contains structure plan of six extracellular C2-type immunoglobulin (Ig) domains followed by five fibronectin typeⅢ domains linked by a single membrane-spanning region to a short cytoplasmic domain. The extracellular portion of CHL1 is higyly glycosylated and involved them in hemophilic disease.

Reference for CHL1

  • Alevizopoulos A, et al. (1997) Regulation of the Transforming Growth Factor beta-responsive Transcription Factor CTF-1 by Calcineurin and Calcium/ Calmodulin-dependent Protein Kinase IV. The Journal of Biological Chemistry. 272: 23597-605.
  • Gerring SL, et al. (1990) The CHL1 (CTF 1) gene product of Saccharomyces cerevisiae is important for chromosome transmission and normal cell cycle progression in G2 / M. EMBO J. 9 (13): 4347-58.
  • Wei MH, et al. (1998) In silico-initiated cloning and molecular characterization of a novel human member of the L1 gene family of neural cell adhesion molecules. Human Genetics. 103 (3): 355-64.

CHL1 Protein

CHL1 protein function

Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). {ECO:0000250}.

CHL1 protein expression

Tissue specificity

Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues.

CHL1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

CHL1 Antibody

There are 6 CHL1 antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Det), ELISA(Cap). There are 5 CHL1 antibody for ELISA, 1 CHL1 antibody for ELISA(Det), 1 CHL1 antibody for ELISA(Cap). Among all these CHL1 antibodies, there are 2 anti-CHL1 mouse monoclonal antibodies , 4 anti-CHL1 rabbit polyclonal antibodies . All the CHL1 anbodies are produced in house and all are in stock. CHL1 antibody customerized service is available.

CHL1 Gene

CHL1 gene / cDNA is a protein-coding gene which located on 3p26.3. The CHL1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.228 organisms have orthologs with human gene CHL1.