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Interferon alpha 2/IFNA2 Protein, Human, Recombinant

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Interferon alpha 2/IFNA2 Protein, Human, Recombinant: Product Information

Purity
> 95 % as determined by SDS-PAGE.
Endotoxin
Please contact us for more information.
Activity
Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus(VSV).
The EC50 for this effect is typically 0.6-4.2pg/mL.
Protein Construction
A DNA sequence encoding the human IFNA2A (P01563.1) (Cys24-Glu188) was expressed.
Accession#
Expressed Host
Yeast
Species
Human
Predicted N Terminal
Cys 24
Molecule Mass
The recombinant human IFNA2A consists 165 amino acids and predicts a molecular mass of 19.3 kDa.
Formulation
Lyophilized from sterile PBS, pH 7.4.
Please contact us for any concerns or special requirements.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the hard copy of CoA.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Interferon alpha 2/IFNA2 Protein, Human, Recombinant: Images

Measured in antiviral assays using WISH human amnion cells infected with vesicular stomatitis virus(VSV). The EC50 for this effect is typically 0.6-4.2pg/mL.

Interferon alpha 2/IFNA2 Protein, Human, Recombinant: Alternative Names

IFN-alphaA Protein, Human; IFNA Protein, Human; IFNA2B Protein, Human; IFNAB Protein, Human; INFA2 Protein, Human; Interferon alpha 2 Protein, Human

Interferon alpha 2/IFNA2 Background Information

Type I Interferons (IFNs) are well known cytokines which exert antiviral activity, antitumor activity and immunomodulatory effects. Interferon tau (IFNT), a type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal produced by the ruminant conceptus. Among IFN-α genes, a total of 28 different sequence variants have been described.The three principal subtypes of IFNα-2 are designated α-2a, α-2b, and α-2c. IFNα-2b is being the predominant allele while IFNα-2a is less predominant and IFNα-2c only a minor allelic variant.
Full Name
interferon, alpha 2
References
  • Wang, et al. (2004) Fever of recombinant human interferon-alpha is mediated by opioid domain interaction with opioid receptor inducing prostaglandin E2. J Neuroimmunol. 156(1-2): 107-12.
  • Groopman JE, et al. (1984) Recombinant alpha-2 interferon therapy for Kaposi's sarcoma associated with the acquired immunodeficiency syndrome. Ann Intern Med. 100(5): 671-6.
  • Krueger JM, et al. (1987) Interferon alpha-2 enhances slow-wave sleep in rabbits. Int J Immunopharmacol. 9(1): 23-30.
  • Purification of target proteins from intracellular inclusions mediated by intein cleavable polyhydroxyalkanoate synthase fusions
    Author
    Du, J;Rehm, BHA;
    Year
    2017
    Journal
    Microb. Cell Fact.
  • Luteolin-7-O-Glucoside Present in Lettuce Extracts Inhibits Hepatitis B Surface Antigen Production and Viral Replication by Human Hepatoma Cells in Vitro
    Author
    Cui, XX;Yang, X;Wang, HJ;Rong, XY;Jing, S;Xie, YH;Huang, DF;Zhao, C;
    Year
    2017
    Journal
    Front Microbiol
    Application
    cell-based
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