PDGFRB cDNA Clone: Expression and Clone Vector / Plasmid

PDGFRB cDNA / Gene Overview

PDGFRB gene / cDNA is a protein-coding gene which located on 5q32. The PDGFRB gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.230 organisms have orthologs with human gene PDGFRB.

PDGFRB cDNA / Gene Function

The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]

PDGFRB cDNA / Gene Sequence

LOCUS
LOCUS NM_002609 5718 bp mRNA linear PRI 03-JUN-2018
DEFINITION
Homo sapiens platelet derived growth factor receptor beta (PDGFRB), transcript variant 1, mRNA.
ACCESSION
NM_002609
VERSION
NM_002609.3

This sequence information is just for reference only.

PDGFRB Family & Reagents

PDGFRB Gene family reagents (Receptor Tyrosine Kinases)

Approved Symbol Reagent list
FLT3
PDGFRA
RET
DDR1
ROR1
INSR
AXL
NTRK1
KIT
TEK
Approved Symbol Reagent list
MET
FLT4
Tie1
ROR2
KDR
FGFR1
FGFR3
FGFR4
MERTK
DDR2

PDGFRB Gene family reagents (CD molecules)

Approved Symbol Reagent list
PSG1
FCGR3B
BMPR1A
SDC2
CD1B
CDH1
CD58
TFRC
BMPR1B
CD46
Approved Symbol Reagent list
FCRL2
ICOS
CD14
CLEC7A
CD52
LILRA1
CD82
SDC1
Clec9a
CD7

PDGFRB Gene family reagents (I-set domain containing)

Approved Symbol Reagent list
CNTN3
IGFBP7
SPEG
OPCML
NPTN
KDR
CADM2
LRRN3
NRG2
IL1R1
Approved Symbol Reagent list
FGFR4
ROR1
CNTN4
WFIKKN2
IGSF11
SIGLEC6
IL1RAPL1
MAG
VCAM1
NRG1

PDGFRB Gene family reagents (Immunoglobulin like domain containing)

Approved Symbol Reagent list
CADM3
PVR
ICAM5
IL12B
CADM4
ICAM1
FLT1
KIRREL2
IL11RA
CHL1
Approved Symbol Reagent list
CD48
CEACAM5
MDGA2
KDR
SEMA3A
IL1RAP
CEACAM6
CNTN1
ALCAM
ESAM

PDGFRB cDNA / Gene Alias

  • CD140b
  • JTK12
  • PDGFR1

PDGFRB cDNA / Gene Expression

Broad expression in gall bladder (RPKM 79.5), placenta (RPKM 61.0) and 21 other tissues