Anti-PDGFRB Antibody (PE)

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Anti-PDGFRB Antibody (PE) (Mouse Monoclonal antibody) General Information

Product name
Anti-PDGFRB Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human PDGFRB
Immunogen
Recombinant Human PDGFRB / CD140b Protein (Catalog#10514-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PDGFRB / CD140b (rh PDGFRB / CD140b; Catalog#10514-H08H; NP_002600.1; Met1-Lys531) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Mouse IgG1 Clone #11
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PE
Concentration
5 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-PDGFRB Antibody (PE) (Mouse Monoclonal antibody) Images

Flow cytometric analysis of Human PDGFRβ (CD140b) expression on MG63 cells. Cells were stained with PE-conjugated anti-Human PDGFRβ (CD140b). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-PDGFRB Antibody (PE): Alternative Names

Anti-CD140B Antibody; Anti-IBGC4 Antibody; Anti-IMF1 Antibody; Anti-JTK12 Antibody; Anti-KOGS Antibody; Anti-PDGFR Antibody; Anti-PDGFR-1 Antibody; Anti-PDGFR1 Antibody; Anti-PENTT Antibody

PDGFRB Background Information

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 32 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD14b, also known as PDGFRB, is a member of the CD system. CD14b is a cell surface tyrosine kinase receptor essencial for development interacting with the platelet-derived growth factors (PDGFs) which serves as mitogens for mesenchymal cells. CD14b can bind with platelet-derived growth factor (PDGF)-B, that are secreted by tumors and phosphorylation of PDGFR-β was correlated with depth of cancer invasion at statistically significant level.
Full Name
platelet-derived growth factor receptor, beta polypeptide
References
  • Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
  • Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
  • Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
  • Suzuki S, et al. (2010) Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor- phosphorylation, and microvessel density in gastric cancer. BMC cancer. 10: 659.

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