PD-1: PD-1 Protein | PD-1 Antibody

PD-1 Gene family

PD-1 Background

Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-1 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.

Reference for PD-1

  • James ES, et al. (2005) PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders. Genes Immun. 6(5): 430-7.
  • Okazaki T, et al. (2007) PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol. 19(7): 813-24.
  • del Rio ML, et al. (2008) PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transpl Int. 21(11): 1015-28.
  • Riley JL.(2009) PD-1 signaling in primary T cells. Immunol Rev. 229(1): 114-25.

PD-1 Protein

PD-1 protein function

Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors. {ECO:0000269|PubMed:21276005}.

PD-1 protein expression

Induction

Induced at programmed cell death.

PD-1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    288.00
  • Mass (Da)
    31.00

PD-1 Antibody

There are 41 PD-1 antibodies which are validated in multiple tissues with various applications, including Neutralization, FCM, ELISA(Cap), ELISA, IHC-P, ELISA(Det), WB, IP. There are 3 PD-1 antibody for Neutralization, 14 PD-1 antibody for FCM, 2 PD-1 antibody for ELISA(Cap), 20 PD-1 antibody for ELISA, 6 PD-1 antibody for IHC-P, 1 PD-1 antibody for ELISA(Det), 2 PD-1 antibody for WB, 2 PD-1 antibody for IP. Among all these PD-1 antibodies, there are 2 anti-PD-1 , 24 anti-PD-1 mouse monoclonal antibodies , 5 anti-PD-1 rabbit monoclonal antibodies , 10 anti-PD-1 rabbit polyclonal antibodies . All the PD-1 anbodies are produced in house and all are in stock. PD-1 antibody customerized service is available.

PD-1 Gene

PDCD1 gene / cDNA is a protein-coding gene which located on 2q37.3. The PDCD1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.168 organisms have orthologs with human gene PDCD1.