PD-L1 cDNA Clone: Expression and Clone Vector / Plasmid
PD-L1 cDNA / Gene Overview
CD274 gene / cDNA is a protein-coding gene which located on 9p24.1. The CD274 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.160 organisms have orthologs with human gene CD274.
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
PD-L1 cDNA / Gene Sequence
LOCUS NM_014143 3691 bp mRNA linear PRI 12-AUG-2018
Homo sapiens CD274 molecule (CD274), transcript variant 1, mRNA.
This sequence information is just for reference only.
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