PD-L1: PD-L1 Protein | PD-L1 Antibody

PD-L1 Gene family

PD-L1 Background

Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

Reference for PD-L1

  • Iwai Y, et al. (2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A. 99(19): 12293-7.
  • Ghebeh H, et al. (2006) The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. Neoplasia. 8(3): 190-8.
  • Salih HR, et al. (2006) The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans. Exp Hematol. 34(7): 888-94.
  • Wilcox RA, et al. (2009) B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Blood. 114(10): 2149-58.
  • Ruggiero A, et al. (2009) Crystal structure of PD-L1, a ribosome inactivating protein from Phytolacca dioica L. leaves with the property to induce DNA cleavage. Biopolymers. 91(12): 1135-42.

PD-L1 Protein

PD-L1 protein function

Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443, ECO:0000269|PubMed:28813410, ECO:0000269|PubMed:28813417}.

PD-L1 protein expression

Tissue specificity

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

Induction

Up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation. Up-regulated in B-cells activated by surface Ig cross-linking.

PD-L1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    290.00
  • Mass (Da)
    33.00

PD-L1 Antibody

There are 35 PD-L1 antibodies which are validated in multiple tissues with various applications, including IHC-P, ELISA, WB, IP, FCM, ELISA(Cap), ELISA(Det), Neutralization, ICC/IF. There are 3 PD-L1 antibody for IHC-P, 14 PD-L1 antibody for ELISA, 2 PD-L1 antibody for WB, 2 PD-L1 antibody for IP, 16 PD-L1 antibody for FCM, 1 PD-L1 antibody for ELISA(Cap), 1 PD-L1 antibody for ELISA(Det), 1 PD-L1 antibody for Neutralization, 1 PD-L1 antibody for ICC/IF. Among all these PD-L1 antibodies, there are 10 anti-PD-L1 mouse monoclonal antibodies , 16 anti-PD-L1 rabbit monoclonal antibodies , 9 anti-PD-L1 rabbit polyclonal antibodies . All the PD-L1 anbodies are produced in house and all are in stock. PD-L1 antibody customerized service is available.

PD-L1 Gene

CD274 gene / cDNA is a protein-coding gene which located on 9p24.1. The CD274 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.160 organisms have orthologs with human gene CD274.