PVRL1 / NECTIN1: PVRL1 / NECTIN1 Protein | PVRL1 / NECTIN1 Antibody

PVRL1 / NECTIN1 Gene family

PVRL1 / NECTIN1 Background

Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin-1; CD111), also known as PVRL1 is a cell adhesion molecule belonging to the immunoglobulin superfamily that can bind to virion glycoprotein D (gD) to mediate entry of herpes simplex viruses (HSV) and pseudorabies virus (PRV). CD111/Nectin-1/PVRL1 colocalizes with E-cadherin at adherens junctions in epithelial cells. The disruption of cell junctions can result in the redistribution of nectin-1. To determine whether disruption of junctions by calcium depletion influenced the susceptibility of epithelial cells to viral entry, Madin-Darby canine kidney cells expressing endogenous nectin-1 or transfected human nectin-1 were tested for the ability to bind soluble forms of viral gD and to be infected by HSV and PRV, before and after calcium depletion. It has been revealed that binding of HSV and PRV gD was localized to adherens junctions in cells maintained in normal medium but was distributed, along with nectin-1, over the entire cell surface after calcium depletion. Both the binding of gD and the fraction of cells that could be infected by HSV-1 and PRV were enhanced by calcium depletion. Taken together, CD111/Nectin-1/PVRL1 confined to adherens junctions in epithelial cells is not very accessible to virus, whereas dissociation of cell junctions releases nectin-1 to serve more efficiently as an entry recptor.

Reference for PVRL1 / NECTIN1

  • Yoon M, et al. (2002) Disruption of adherens junctions liberates nectin-1 to serve as receptor for herpes simplex virus and pseudorabies virus entry. J Virol. 76(14): 7203-8.
  • Mata M, et al. (2001) HveC (nectin-1) is expressed at high levels in sensory neurons, but not in motor neurons, of the rat peripheral nervous system. J Neurovirol. 7(5): 476-80.
  • Haarr L, et al. (2001) Transcription from the gene encoding the herpesvirus entry receptor nectin-1 (HveC) in nervous tissue of adult mouse. Virology. 287(2): 301-9.

PVRL1 / NECTIN1 Protein

PVRL1 / NECTIN1 protein function

Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity.

PVRL1 / NECTIN1 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    517.00
  • Mass (Da)
    57.00

PVRL1 / NECTIN1 Antibody

There are 11 PVRL1 / NECTIN1 antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Det), ELISA(Cap), FCM, WB. There are 6 PVRL1 / NECTIN1 antibody for ELISA, 2 PVRL1 / NECTIN1 antibody for ELISA(Det), 2 PVRL1 / NECTIN1 antibody for ELISA(Cap), 3 PVRL1 / NECTIN1 antibody for FCM, 1 PVRL1 / NECTIN1 antibody for WB. Among all these PVRL1 / NECTIN1 antibodies, there are 5 anti-PVRL1 / NECTIN1 mouse monoclonal antibodies , 4 anti-PVRL1 / NECTIN1 rabbit polyclonal antibodies , 2 anti-PVRL1 / NECTIN1 rabbit monoclonal antibodies . All the PVRL1 / NECTIN1 anbodies are produced in house and all are in stock. PVRL1 / NECTIN1 antibody customerized service is available.

PVRL1 / NECTIN1 Gene

NECTIN1 gene / cDNA is a protein-coding gene which located on 11q23.3. The NECTIN1 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.208 organisms have orthologs with human gene NECTIN1.