Nectin-2: Nectin-2 Protein | Nectin-2 Antibody

Nectin-2 Gene family

Nectin-2 Background

Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

Reference for Nectin-2

  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.

Nectin-2 Protein

Nectin-2 protein function

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). {ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:9657005}.; (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). {ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:9657005}.

Nectin-2 protein expression

Tissue specificity

Ubiquitous.

Nectin-2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    538.00
  • Mass (Da)
    57.00

Nectin-2 Antibody

There are 12 Nectin-2 antibodies which are validated in multiple tissues with various applications, including ELISA, ELISA(Cap), FCM, WB, IP, IHC-P. There are 10 Nectin-2 antibody for ELISA, 1 Nectin-2 antibody for ELISA(Cap), 2 Nectin-2 antibody for FCM, 2 Nectin-2 antibody for WB, 2 Nectin-2 antibody for IP, 1 Nectin-2 antibody for IHC-P. Among all these Nectin-2 antibodies, there are 1 anti-Nectin-2 mouse monoclonal antibodies , 5 anti-Nectin-2 rabbit monoclonal antibodies , 6 anti-Nectin-2 rabbit polyclonal antibodies . All the Nectin-2 anbodies are produced in house and all are in stock. Nectin-2 antibody customerized service is available.

Nectin-2 Gene

NECTIN2 gene / cDNA is a protein-coding gene which located on 19q13.32. The NECTIN2 gene is conserved in chimpanzee, dog, mouse, and rat.131 organisms have orthologs with human gene NECTIN2.