Insulin Receptor cDNA ORF Clone, Mouse, untagged

INSR (Insulin receptor), also known as CD22, is a transmembrane receptor that is activated by insulin. INSR belongs to theprotein kinase superfamily, and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). IRS-1 binding and phosphorylation eventually leads to an increase in the high affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues. INSR isoform long and isoform short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin, and is found as a hybrid receptor with IGF1R which also binds IGF1 in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibrobasts, spleen and placenta. Defects in Insulin Receptor/INSR are the cause of Rabson-Mendenhall syndrome (Mendenhall syndrome), insulin resistance (Ins resistance), leprechaunism (Donohue syndrome), and familial hyperinsulinemic hypoglycemia 5 (HHF5). It may also be associated with noninsulin-dependent diabetes mellitus (NIDDM).

insulin receptor

• Cardiovascular>>Atherosclerosis>>diabetes-associated atherosclerosis
• Developmental Biology>>Post embryonic development>>Cellular Senescence & Aging>>GH/IGF-I Axis
• Cancer>>Signal Transduction>>Other Related Intracellular Topics>>Cellular Senescence and Pathways in Aging>>Growth Hormone/IGF-I Axis
• Cardiovascular>>Angiogenesis>>Growth Factor & Receptor>>Insulin-like Growth Factor (IGF) System>>IGF Receptor
• Stem Cells>>Neural Stem Cells (NSCs)>>Mesenchymal Stem Cell (MSC) Marker
• Developmental Biology>>Metabolism>>Types of disease>>Metabolism in Cancer
• Developmental Biology>>Metabolism>>Types of disease>>Metabolism in Diabetes
• Developmental Biology>>Metabolism>>Types of disease>>Metabolism in Heart disease
• Immunology>>Cluster of Differentiation (CD)>>Other CD Antigen
• Stem Cells>>Stem Cell Differentiation Stage Marker>>Pancreatic Cell Marker
• Cardiovascular>>Angiogenesis>>Growth Factor & Receptor>>Receptor Tyrosine Kinase (RTK)
• Cancer>>Signal Transduction>>Protein Phosphorylation>>Tyrosine Kinase>>Receptor Tyrosine Kinases
• Cancer>>Signal Transduction>>Receptor Tyrosine Kinases (RTKs)
• Cancer>>Signal Transduction>>Akt Pathway>>Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
• Cancer>>Signal Transduction>>Jak/STAT Signaling>>Receptors in the Jak/STAT Pathway

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• Ullrich A., et al., (1985), Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.Nature 313:756-761.
• Grimwood J., et al.,(2004), The DNA sequence and biology of human chromosome 19.Nature 428:529-535.