LIFR: LIFR Protein | LIFR Antibody

LIFR Gene family

LIFR Background

LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp13, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (cardiotrophin like cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1 and cardiotrophin like cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF5) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths.

Reference for LIFR

  • Gearing, D.P. et al.,1991, EMBO J. 10 (10): 2839-2848.
  • Gearing, D.P. et al.,1992, New Biol. 4 (1): 61-65.
  • Mosley, B. et al.,1996, J. Biol. Chem. 271 (51): 32635-32643.
  • Timmermann, A. et al.,2002, Eur. J. Biochem. 269 (11): 2716-2726.
  • Lass, A. et al.,2002, Fertil. Steril. 76 (6): 1091-1096.

LIFR Protein

LIFR protein function

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.

LIFR protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    1,097.00
  • Mass (Da)
    123.00

LIFR Antibody

There are 11 LIFR antibodies which are validated in multiple tissues with various applications, including ELISA, IHC-P, WB, ELISA(Cap). There are 10 LIFR antibody for ELISA, 2 LIFR antibody for IHC-P, 2 LIFR antibody for WB, 1 LIFR antibody for ELISA(Cap). Among all these LIFR antibodies, there are 3 anti-LIFR mouse monoclonal antibodies , 2 anti-LIFR rabbit monoclonal antibodies , 6 anti-LIFR rabbit polyclonal antibodies . All the LIFR anbodies are produced in house and all are in stock. LIFR antibody customerized service is available.

LIFR Gene

LIFR gene / cDNA is a protein-coding gene which located on 5p13.1. The LIFR gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.186 organisms have orthologs with human gene LIFR.