LIF cDNA Clone: Expression and Clone Vector / Plasmid

LIF cDNA / Gene Overview

LIF gene / cDNA is a protein-coding gene which located on 22q12.2. The LIF gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.171 organisms have orthologs with human gene LIF.

LIF cDNA / Gene Function

The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

LIF cDNA / Gene Sequence

LOCUS
LOCUS NM_002309 3987 bp mRNA linear PRI 25-JUN-2018
DEFINITION
Homo sapiens LIF, interleukin 6 family cytokine (LIF), transcript variant 1, mRNA.
ACCESSION
NM_002309
VERSION
NM_002309.4

This sequence information is just for reference only.

LIF Family & Reagents

LIF Gene family reagents (Endogenous ligands)

Approved Symbol Reagent list
CCL11
FGF2
CCL26
PDCD1LG2
NCR3LG1
FGF9
CCL21
CALCB
CXCL1
F2
Approved Symbol Reagent list
RSPO1
PROK1
CCL3
XCL2
INHBA
FLT3LG
VIP
GHRH
CXCL16
BMP2

LIF Gene family reagents (Interleukin 6 type cytokine family)

Approved Symbol Reagent list
CLCF1
CTF1
IL6
Approved Symbol Reagent list
CNTF
IL11
OSM

LIF cDNA / Gene Alias

  • CDF
  • cholinergic differentiation factor
  • DIA
  • differentiation inhibitory activity
  • differentiation-inducing factor
  • hepatocyte-stimulating factor III
  • HILDA
  • human interleukin in DA cells

LIF cDNA / Gene Expression

Broad expression in gall bladder (RPKM 20.9), appendix (RPKM 11.6) and 16 other tissues