Anti-LDLR / LDL Receptor Antibody

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Anti-LDLR / LDL Receptor Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-LDLR / LDL Receptor Antibody
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human LDLR / LDL Receptor
Immunogen
Recombinant Human LDL Receptor / LDLR Protein (Catalog#10231-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human LDL Receptor / LDLR (rh LDL Receptor / LDLR; Catalog#10231-H08H; NP_000518.1; Met1-Arg788).
Source
Monoclonal Rabbit IgG Clone #301
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-LDLR / LDL Receptor Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
FCM 1:25-1:100
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-LDLR / LDL Receptor Antibody (Rabbit Monoclonal antibody) Images

Flow cytometric analysis of Human LDLR expression on HepG2 cells. Cells were stained with purified anti-Human LDLR, then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-LDLR / LDL Receptor Antibody: Alternative Names

Anti-FH Antibody; Anti-FHC Antibody; Anti-LDL R Antibody; Anti-LDL Receptor Antibody; Anti-LDLCQ2 Antibody

LDLR / LDL Receptor Background Information

LDL Receptor, also known as LDLR, is a mosaic protein which belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 84 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B1 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.
Full Name
low density lipoprotein receptor
References
  • Yamamoto T, et al. (1984) The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA. Cell. 39(1): 27-38.
  • Mao B, et al. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 411(6835): 321-5.
  • Pinson KI, et al. (2000) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 407(6803): 535-8.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

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Mouse MAb

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