Anti-TIM-1 / KIM-1 Antibody

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Anti-TIM-1 / KIM-1 Antibody (Mouse Monoclonal antibody) General Information

Product name
Anti-TIM-1 / KIM-1 Antibody
Validated applications
ELISA,ELISA(Det)
Species reactivity
Reacts with: Human
Specificity
Human TIM-1 / KIM-1
No cross-reactivity in ELISA with
Mouse KIM1
Human TIMD3
Rat KIM1
Human TIMD4
Human cell lysate (293 cell line)
Immunogen
Recombinant Human KIM-1 / TIM1 / HACVR1 protein (Catalog#11051-H07H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human KIM-1 / TIM1 / HACVR1 (rh KIM-1 / TIM1 / HACVR1; Catalog#11051-H07H; AAC39862.1; Ser 21-Gly 290). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #10B8C11
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-TIM-1 / KIM-1 Antibody (Mouse Monoclonal antibody) Validated Applications

Application Dilution
ELISA 1:1000-1:2000
ELISA(Det) 1:1000-1:10000
Notes
ELISA(Det): This antibody will detect Human KIM-1 / TIM1 / HACVR1 in ELISA pair set (Catalog: # SEK11051). In a sandwich ELISA, it can be used as detection antibody when paired with (Catalog: # 11051-MM06).
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-TIM-1 / KIM-1 Antibody: Alternative Names

Anti-CD365 Antibody; Anti-HACVR Antibody; Anti-HAVCR Antibody; Anti-HAVCR-1 Antibody; Anti-KIM-1 Antibody; Anti-KIM1 Antibody; Anti-TIM Antibody; Anti-TIM-1 Antibody; Anti-TIM1 Antibody; Anti-TIMD-1 Antibody; Anti-TIMD1 Antibody

TIM-1 / KIM-1 Background Information

HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â… integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.
Full Name
hepatitis A virus cellular receptor 1
References
  • Tami C, et al. (2007) Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. J Virol. 81(7): 3437-46.
  • Rees AJ, et al. (2008) Kim-1/Tim-1: from biomarker to therapeutic target? Nephrol Dial Transplant. 23(11): 3394-6.
  • Chaturvedi S, et al. (2009) Assay validation for KIM-1: human urinary renal dysfunction biomarker. Int J Biol Sci. 5(2): 128-34.

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