IL21 Receptor Protein

IL21 Receptor Protein Overview

IL21 Receptor reagents

By scanning the genome for 'virtual' open reading frames using a gene prediction program and BLAST comparisons, followed by nested RT-PCR of various immune system tissues, Ozaki et al. (2000) identified a cDNA encoding IL21R, which they called NILR (novel interleukin receptor). Sequence analysis predicted that the deduced 538-amino acid IL21R protein, which is most closely related to human IL2RB (146710) and is 62% identical to mouse Il21r, contains 4 conserved cys residues, 5 potential N-linked glycosylation sites, numerous potential O-linked glycosylation sites, and a WSXWS motif in the extracellular region, typical of type I cytokine receptors. IL21R also has a Box 1 region in its intracellular region. Immunoprecipitation and Western blot analysis revealed the expression of an 80- to 100-kD IL21R protein on NK-, T-, and B-cell lines and showed that IL21R associates with JAK1 (147795). By searching an EST database, Parrish-Novak et al. (2000) also identified a cDNA encoding IL21R. In addition to the motifs reported by Ozaki et al. (2000), Parrish-Novak et al. (2000) noted the presence of an intracellular Box 2 motif as an additional potential signaling sequence in IL21R. Northern blot analysis detected IL21R transcripts only in lymphoid tissue. In situ hybridization analysis detected IL21R mRNA in a subset of cells in normal lymphoid tissue and in fibrotic but not normal lung. Flow cytometric analysis showed that CD23 (151445)-positive B cells, B-cell lines, a T-cell leukemia line, and NK-cell lines express an IL21 (605384)-binding partner. RT-PCR analysis detected IL21R on peripheral NK cells.

IL21 Receptor protein family

Belongs to the type I cytokine receptor family. Type 4 subfamily.

IL21 Receptor protein name

Recommended name
Interleukin-21 receptor
Short name
IL-21 receptor||IL-21R
Alternative name
Novel interleukin receptor CD_antigen: CD360

IL21 Receptor Gene family protein

IL21 Receptor Protein Sequence

Species Human IL21 Receptor protein
Length 538
Mass (Da) 59130
Sequence Human IL21 Receptor protein sequence
Species Mouse IL21 Receptor protein
Length 529
Mass (Da) 58355
Sequence Mouse IL21 Receptor protein sequence
Mass (Da)

IL21 Receptor Protein Molecular Weight & PI

Interleukin-21 receptor precursor (IL-21 receptor) (IL-21R) (Novel interleukin receptor) (CD360 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 20-538 Interleukin-21 receptor.

Molecular weight (Da)


Theoretical pI


IL21 Receptor Protein Structure

Interleukin 21 receptor
2013-12-12   Released:  2014-12-17
Deposition Author(s)
Hamming, O.T., Kang, L., Siupka, P., Gad, H.H., Hartmann, R.
Homo sapiens
Expression System
Homo sapiens
Experimental Data Snapshot
2.7500 Å
R-Value Free
R-Value Work

Human IL21 Receptor protein Secondary structure

IL21 Receptor Protein Interaction

Recombinant IL21 Receptor Protein Feature

IL21 Receptor Protein, Human, Recombinant (His Tag)

High Purity
> 92 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
1. Measured by its ability to bind human IL-21 in a functional ELISA. 2. Measured by its ability to inhibit IL21-induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 1-5 ng/ml in the presence of 10 ng/ml of recombinant human IL21. 3. Measured by its ability to inhibit IL21-induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 50-200 pg/mL in the presence of 1 ng/ml of recombinant human IL21.

Recombinant IL21 Receptor protein citations

Rapid de novo generation of antigen specific human B cells with expression of Blimp-1 and AID by in vitro immunization.
Fang, X;Tong, Y;Tian, H;Ning, H;Gao, X;Yao, W;
Exp. Cell Res

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