Anti-IL-6R Antibody (PE)

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Anti-IL-6R Antibody (PE) (Rabbit Monoclonal antibody) General Information

Product name
Anti-IL-6R Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Mouse
Specificity
Mouse IL-6R
Immunogen
Recombinant Mouse IL-6R / CD126 protein (Catalog#50280-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL-6R / CD126 (rM IL-6R / CD126; Catalog#50280-M08H; NP_034689.2; Ile44-Glu357) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Rabbit IgG Clone #033
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PE
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-IL-6R Antibody (PE) (Rabbit Monoclonal antibody) Images

Profile of anti-IL6Ra/CD126 reactivity on mouse splenocytes analyzed by flow cytometry.

Anti-IL-6R Antibody (PE): Alternative Names

Anti-CD126 Antibody; Anti-IL-6R Antibody; Anti-Il6r Antibody; Anti-MGC30256 Antibody

IL-6R Background Information

Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp13. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp13 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.
Full Name
interleukin 6 receptor
References
  • Barill S, et al. (2000) The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw. 11(4): 546-51.
  • Kang KW, et al. (2007) Novel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells. Free Radic Biol Med. 42(2): 215-27.

Standard Antibody Development Service

Rabbit MAb

Mouse MAb

Rabbit PAb

Fast Antibody Development Service

Mouse MAb

Rabbit PAb

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