ICOS Protein

ICOS Protein Overview

ICOS reagents

The ICOS gene encodes inducible T-cell costimulator, a receptor found on the surface of T cells. The corresponding ligand is encoded by the ICOSLG gene (605717). The T cell-specific cell surface receptors CD28 (186760) and CTLA4 (123890) are important regulators of the immune system. CD28 potently enhances those T-cell functions essential for an effective antigen-specific immune response, and CTLA4 counterbalances the CD28-mediated signals and thus prevents an otherwise fatal overstimulation of the lymphoid system (Hutloff et al., 1999). Yong et al. (2009) reviewed the biology of ICOS and its role in T- and B-cell differentiation and function.

ICOS protein name

Recommended name
Inducible T-cell costimulator
activation-inducible lymphocyte immunomediatory molecule, AILIM, CD278
Alternative name
Activation-inducible lymphocyte immunomediatory molecule CD_antigen: CD278

ICOS Protein Sequence

Species Human ICOS protein
Length 199
Mass (Da) 22625
Sequence Human ICOS protein sequence
Species Mouse ICOS protein
Length 200
Mass (Da) 22709
Sequence Mouse ICOS protein sequence
Species Rat ICOS protein
Length 200
Mass (Da) 22529
Sequence Rat ICOS protein sequence

ICOS Protein Molecular Weight & PI

Inducible T-cell costimulator precursor (Activation-inducible lymphocyte immunomediatory molecule) (CD278 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 21-199 Inducible T-cell costimulator.

Molecular weight (Da)


Theoretical pI


ICOS Protein Interaction

Recombinant ICOS Protein Feature

ICOS Protein, Human, Recombinant (His & Fc Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by its binding ability in a functional ELISA . Immobilized human human B7-H2 at 1 μg/ml (100 μl/well) can bind human ICOS with a linear range of 1.6-200 ng/ml.

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