HVEM Protein

HVEM Protein Overview

HVEM protein name

Recommended name
Tumor necrosis factor receptor superfamily member 14
Aliases
ATAR, CD270, herpesvirus entry mediator, HVEA, HVEM, LIGHTR, TR2
Alternative name
Herpes virus entry mediator A Tumor necrosis factor receptor-like 2 CD_antigen: CD270

HVEM Gene family protein

HVEM Protein Sequence

Species Human HVEM protein
Length 283
Mass (Da) 30392
Sequence Human HVEM protein sequence
Species
Length
Mass (Da)
Sequence
Species
Length
Mass (Da)
Sequence

HVEM Protein Molecular Weight & PI

Tumor necrosis factor receptor superfamily member 14 precursor (Herpes virus entry mediator A) (Herpesvirus entry mediator A) (HveA) (Tumor necrosis factor receptor-like 2) (TR2) (CD270 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 39-283 Tumor necrosis factor receptor

Molecular weight (Da)

26195.85

Theoretical pI

7.05

HVEM Protein Structure

Crystal Structure of HVEM
Deposited
2012-06-06   Released:  2012-07-18
Deposition Author(s)
Liu, W., Zhan, C., Patskovsky, Y., Bhosle, R.C., Nathenson, S.G., Almo, S.C., Atoms-to-Animals: The Immune Function Network (IFN), New York Structural Genomics Research Consortium (NYSGRC)
Organism(s)
Homo sapiens
Expression System
Drosophila melanogaster
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.2510 Å
R-Value Free
0.292
R-Value Work
0.279
4FHQ From PDB

Human HVEM protein Secondary structure

HVEM Protein Interaction

Recombinant HVEM Protein Feature

HVEM Protein, Human, Recombinant (His Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by its binding ability in a functional ELISA. Immobilized recombinant Human HVEM-His(Cat:10334-H08H) at 10 μg/ml (100 μl/well) can bind human BTLA-Fc (Cat:11895-H02H) with a linear range of 1.28-20 μg/ml.

Recombinant HVEM protein citations

Title
Aptamer that binds to the gD protein of herpes simplex virus 1 and efficiently inhibits viral entry
Year
2012
Author
Gopinath, SC;Hayashi, K;Kumar, PK;
Journal
J. Virol.

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