Human cytomegalovirus (HCMV) Glycoprotein B / gB Antibody, Rabbit PAb

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Human cytomegalovirus (HCMV) Glycoprotein B / gB Antibody, Rabbit PAb (Rabbit Polyclonal antibody) General Information

Product name
Human cytomegalovirus (HCMV) Glycoprotein B / gB Antibody, Rabbit PAb
Validated applications
ELISA,IHC-P,FCM,ICC/IF,IP (Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.)
Application notes
(Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.)
Specificity
CMV CMV Glycoprotein B
Immunogen
Recombinant Human cytomegalovirus (HCMV) Glycoprotein B / gB protein (Catalog#10202-V08H1)
Preparation
Produced in rabbits immunized with purified, recombinant Human cytomegalovirus (HCMV) Glycoprotein B / gB (Catalog#10202-V08H1; AAA45920.1; Met1-Lys700 & Arg777-Val907). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Human cytomegalovirus (HCMV) Glycoprotein B / gB Antibody, Rabbit PAb (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

CMV Glycoprotein B Background Information

Cytomegalovirus (CMV) (human herpesvirus 5) glycoprotein B, also referred as CMV gB or gB, which belongs to the herpesviridae glycoprotein B family. It is a 97-amino acid glycoprotein encoded by the ORF of UL55. Cytomegalovirus Glycoprotein B protein is the most abundant component of the envelope, a target of neutralizing antibodies with at least two defined neutralizing epitopes and an essential replication component. Cytomegalovirus Glycoprotein B protein plays important roles in HCMV entry, cell-cell spread of internal virions, and fusion of infected cells. In addition, Cytomegalovirus Glycoprotein B protein is one envelope protein capable of heparin binding. It forms a physical association with host cell annexin II independent of the presence of calcium.
References
  • Lopper M,et al. (2002). Disulfide bond configuration of human cytomegalovirus glycoprotein B. J Virol. 76(12): 6073-82.
  • Isaacson MK, et al. (2009) Human cytomegalovirus glycoprotein B is required for virus entry and cell-to-cell spread but not for virion attachment, assembly, or egress. J Virol. 83(8): 3891-903.
  • Fine Mapping the Interaction Between Dendritic CellSpecific Intercellular Adhesion Molecule (ICAM)-3- Grabbing Nonintegrin and the Cytomegalovirus Envelope Glycoprotein B
    Author
    Cheneau, C;Coulon, F;Porkolab, V;Fieschi, F;Laurant, S;
    Year
    2018
    Journal
    The Journal of Infectious Diseases
    Application
    WB
  • Fine-mapping the interaction between DC-SIGN and the cytomegalovirus envelope glycoprotein B
    Author
    Chéneau, C;Coulon, F;Porkolab, V;Fieschi, F;Laurant, S;Razanajaona-Doll, D;Pin, JJ;Borst, EM;Messerle, M;Bressollette-Bodin, C;Halary, F;
    Year
    2018
    Journal
    J. Infect. Dis.
    Application
    binding (inhibition)

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