Her2 / ERBB2 (Protein | Antibody | cDNA Clone | ELISA Kit)

All Her2 / ERBB2 reagents are produced in house and quality controlled, including 38 Her2 / ERBB2 Antibody, 2 Her2 / ERBB2 ELISA, 39 Her2 / ERBB2 Gene, 2 Her2 / ERBB2 IP Kit, 17 Her2 / ERBB2 Lysate, 20 Her2 / ERBB2 Protein, 3 Her2 / ERBB2 qPCR. All Her2 / ERBB2 reagents are ready to use.

All Her2 / ERBB2 Reagents

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Her2 / ERBB2 Background

Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD34, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

Her2 / ERBB2 References

  • Krawczyk N, et al. (2009) HER2 status on persistent disseminated tumor cells after adjuvant therapy may differ from initial HER2 status on primary tumor. Anticancer Res. 29(10): 4019-24.