GITR: GITR Protein | GITR Antibody

GITR Gene family

GITR Background

GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.

Reference for GITR

  • Kwon B, et al. (1999) Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. J Biol Chem. 274(10):6056-61.
  • Nocentini G, et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci. 94(12): 6216-21.
  • Baltz KM, et al. (2007) Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. FASEB J. 21(10):2442-54.

GITR Protein

GITR protein function

Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

GITR protein expression

Tissue specificity

Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.

Induction

Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

GITR protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    241.00
  • Mass (Da)
    26.00

GITR Antibody

There are 4 GITR antibodies which are validated in multiple tissues with various applications, including ELISA. There are 4 GITR antibody for ELISA. Among all these GITR antibodies, there are 1 anti-GITR mouse monoclonal antibodies , 1 anti-GITR rabbit monoclonal antibodies , 2 anti-GITR rabbit polyclonal antibodies . All the GITR anbodies are produced in house and all are in stock. GITR antibody customerized service is available.

GITR Gene

TNFRSF18 gene / cDNA is a protein-coding gene which located on 1p36.33. The TNFRSF18 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.178 organisms have orthologs with human gene TNFRSF18.