GITR cDNA Clone: Expression and Clone Vector / Plasmid

GITR cDNA / Gene Overview

TNFRSF18 gene / cDNA is a protein-coding gene which located on 1p36.33. The TNFRSF18 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.178 organisms have orthologs with human gene TNFRSF18.

GITR cDNA / Gene Function

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]

GITR cDNA / Gene Sequence

LOCUS
LOCUS NM_004195 1214 bp mRNA linear PRI 23-JUN-2018
DEFINITION
Homo sapiens TNF receptor superfamily member 18 (TNFRSF18), transcript variant 1, mRNA.
ACCESSION
NM_004195
VERSION
NM_004195.2

This sequence information is just for reference only.

GITR Family & Reagents

GITR Gene family reagents (CD molecules)

Approved Symbol Reagent list
CD1B
TNFSF13
PDGFRA
CD84
NECTIN1
CD86
LEPR
TLR4
CD83
FGFR4
Approved Symbol Reagent list
PTGFRN
IL1R1
CD27
CD70
KIR2DL5A
CDCP1
BST1
ANPEP
ENPEP
F11R

GITR Gene family reagents (Tumor necrosis factor receptor superfamily)

Approved Symbol Reagent list
TNFRSF21
FAS
LTBR
TNFRSF12A
RELT
TNFRSF10C
TNFRSF8
TNFRSF17
TNFRSF10D
TNFRSF6B
Approved Symbol Reagent list
TNFRSF11A
TNFRSF4
TNFRSF25
TNFRSF13B
EDA2R
EDAR
TNFRSF1B
TNFRSF11B
CD40
TNFRSF9

GITR cDNA / Gene Alias

  • AITR
  • CD357
  • GITR

GITR cDNA / Gene Expression

Biased expression in skin (RPKM 4.0), appendix (RPKM 1.0) and 12 other tissues