Factor D cDNA Clone: Expression and Clone Vector / Plasmid

Factor D cDNA / Gene Overview

CFD gene / cDNA is a protein-coding gene which located on 19p13.3. The CFD gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.120 organisms have orthologs with human gene CFD.

Factor D cDNA / Gene Function

This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]

Factor D cDNA / Gene Sequence

LOCUS
LOCUS NM_001928 1124 bp mRNA linear PRI 01-JUL-2018
DEFINITION
Homo sapiens complement factor D (CFD), transcript variant 1, mRNA.
ACCESSION
NM_001928
VERSION
NM_001928.3

This sequence information is just for reference only.

Factor D Family & Reagents

Gene family

Factor D Gene family reagents (Complement system)

Approved Symbol Reagent list
C1QB
C5
C7
CD59
CFH
CFHR2
Approved Symbol Reagent list
C2
C6
CD46
CFB
CFHR1
CR2

Factor D cDNA / Gene Alias

  • adipsin
  • ADN

Factor D cDNA / Gene Expression

Biased expression in fat (RPKM 584.9), colon (RPKM 88.4) and 1 other tissue