Factor D cDNA Clone: Expression and Clone Vector / Plasmid
Factor D cDNA / Gene Overview
CFD gene / cDNA is a protein-coding gene which located on 19p13.3. The CFD gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.120 organisms have orthologs with human gene CFD.
This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]
Factor D cDNA / Gene Sequence
LOCUS NM_001928 1124 bp mRNA linear PRI 01-JUL-2018
Homo sapiens complement factor D (CFD), transcript variant 1, mRNA.
This sequence information is just for reference only.
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