EpCAM: EpCAM Protein | EpCAM Antibody

EpCAM Gene family

EpCAM Background

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

Reference for EpCAM

  • Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10.
  • Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5.
  • Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.
  • Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6.

EpCAM Protein

EpCAM protein function

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E. {ECO:0000269|PubMed:15195135, ECO:0000269|PubMed:15922867, ECO:0000269|PubMed:19785009, ECO:0000269|PubMed:20064925}.

EpCAM protein expression

Tissue specificity

Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.

EpCAM protein sequence

This sequence information is just for reference only.From Uniport

  • Length
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EpCAM Antibody

There are 21 EpCAM antibodies which are validated in multiple tissues with various applications, including WB, IP, FCM, ELISA, ELISA(Cap), ELISA(Det), IHC-P, ICC/IF. There are 6 EpCAM antibody for WB, 4 EpCAM antibody for IP, 8 EpCAM antibody for FCM, 11 EpCAM antibody for ELISA, 2 EpCAM antibody for ELISA(Cap), 2 EpCAM antibody for ELISA(Det), 6 EpCAM antibody for IHC-P, 1 EpCAM antibody for ICC/IF. Among all these EpCAM antibodies, there are 6 anti-EpCAM mouse monoclonal antibodies , 7 anti-EpCAM rabbit monoclonal antibodies , 8 anti-EpCAM rabbit polyclonal antibodies . All the EpCAM anbodies are produced in house and all are in stock. EpCAM antibody customerized service is available.

EpCAM Gene

EpCAM gene / cDNA is a protein-coding gene which located on 2p21. The EPCAM gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.220 organisms have orthologs with human gene EPCAM.