E-Cadherin: E-Cadherin Protein | E-Cadherin Antibody

E-Cadherin Gene family

E-Cadherin Background

Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas.

Reference for E-Cadherin

  • Wang HD, et al. (2004) CDH1 germline mutation in hereditary gastric carcinoma. World J Gastroenterol. 10(21): 3088-93.
  • Masterson J, et al. (2007) Posttranslational truncation of E-cadherin and significance for tumour progression. Cells Tissues Organs. 185(1-3): 175-9.
  • Mrgineanu E, et al. (2008) Correlation between E-cadherin abnormal expressions in different types of cancer and the process of metastasis. Rev Med Chir Soc Med Nat Iasi. 112(2): 432-6.

E-Cadherin Protein

E-Cadherin protein function

Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:16417575}.; E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {ECO:0000269|PubMed:16417575}.

E-Cadherin protein expression

Tissue specificity

Non-neural epithelial tissues.

Induction

Expression is repressed by MACROD1.

E-Cadherin protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    882.00
  • Mass (Da)
    97.00

E-Cadherin Antibody

There are 21 E-Cadherin antibodies which are validated in multiple tissues with various applications, including ELISA(Cap), ICC/IF, ELISA, FCM, IHC-P, WB, IP. There are 1 E-Cadherin antibody for ELISA(Cap), 7 E-Cadherin antibody for ICC/IF, 13 E-Cadherin antibody for ELISA, 4 E-Cadherin antibody for FCM, 5 E-Cadherin antibody for IHC-P, 6 E-Cadherin antibody for WB, 4 E-Cadherin antibody for IP. Among all these E-Cadherin antibodies, there are 8 anti-E-Cadherin mouse monoclonal antibodies , 5 anti-E-Cadherin rabbit monoclonal antibodies , 8 anti-E-Cadherin rabbit polyclonal antibodies . All the E-Cadherin anbodies are produced in house and all are in stock. E-Cadherin antibody customerized service is available.

E-Cadherin Gene

CDH1 gene / cDNA is a protein-coding gene which located on 16q22.1. The CDH1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.136 organisms have orthologs with human gene CDH1.