DR5 / TRAIL R2 cDNA Clone: Expression and Clone Vector / Plasmid

DR5 / TRAIL R2 cDNA / Gene Overview

TNFRSF10B gene / cDNA is a protein-coding gene which located on 8p21.3. The TNFRSF10B gene is conserved in chimpanzee, Rhesus monkey, chicken, and frog.48 organisms have orthologs with human gene TNFRSF10B.

DR5 / TRAIL R2 cDNA / Gene Function

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

DR5 / TRAIL R2 cDNA / Gene Sequence

LOCUS
LOCUS NM_147187 4067 bp mRNA linear PRI 15-JUL-2018
DEFINITION
Homo sapiens TNF receptor superfamily member 10b (TNFRSF10B), transcript variant 2, mRNA.
ACCESSION
NM_147187
VERSION
NM_147187.2

This sequence information is just for reference only.

DR5 / TRAIL R2 Family & Reagents

DR5 / TRAIL R2 Gene family reagents (CD molecules)

Approved Symbol Reagent list
CSF2RA
BCAM
SLAMF6
ADAM8
ADAM17
FZD4
CTLA4
CD4
LAMP2
CD177
Approved Symbol Reagent list
CD207
IL13Ra2
Clec9a
TNFSF10
MELTF
KLRC1
PROM1
LAG3
TEK
CD19

DR5 / TRAIL R2 Gene family reagents (Tumor necrosis factor receptor superfamily)

Approved Symbol Reagent list
TNFRSF8
CD40
TNFRSF19
RELT
TNFRSF13C
TNFRSF13B
TNFRSF18
TNFRSF11B
EDAR
TNFRSF10C
Approved Symbol Reagent list
TNFRSF10A
CD27
TNFRSF1B
TNFRSF17
EDA2R
TNFRSF9
TNFRSF6B
TNFRSF21
FAS
NGFR

DR5 / TRAIL R2 cDNA / Gene Alias

  • CD262
  • DR5
  • KILLER
  • TRAILR2
  • TRAIL-R2
  • TRICK2A
  • TRICKB

DR5 / TRAIL R2 cDNA / Gene Expression

Ubiquitous expression in gall bladder (RPKM 17.8), urinary bladder (RPKM 14.8) and 25 other tissues

Recombinant DR5 / TRAIL R2 protein citations

Title
A Novel Fully Human Agonistic Single Chain Fragment Variable Antibody Targeting Death Receptor 5 with Potent Antitumor Activity In Vitro and In Vivo
Year
2017
Author
Lei, G;Xu, M;Xu, Z;Gu, L;Lu, C;Bai, Z;Wang, Y;Zhang, Y;Hu, H;Jiang, Y;Zhao, W;Tan, S;
Journal
Int J Mol Sci