TNFRSF10B gene / cDNA is a protein-coding gene which located on 8p21.3. The TNFRSF10B gene is conserved in chimpanzee, Rhesus monkey, chicken, and frog.48 organisms have orthologs with human gene TNFRSF10B.
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
DR5 / TRAIL R2 cDNA / Gene Sequence
LOCUS NM_147187 4067 bp mRNA linear PRI 15-JUL-2018
Homo sapiens TNF receptor superfamily member 10b (TNFRSF10B), transcript variant 2, mRNA.
This sequence information is just for reference only.
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