DR4 / TRAIL R1 Protein

DR4 / TRAIL R1 Protein Overview

DR4 / TRAIL R1 protein name

Recommended name
Tumor necrosis factor receptor superfamily member 10A
Aliases
Apo2, CD261, DR4, TRAILR1, TRAILR-1
Alternative name
Death receptor 4 TNF-related apoptosis-inducing ligand receptor 1 CD_antigen: CD261

DR4 / TRAIL R1 Gene family protein

DR4 / TRAIL R1 Protein Sequence

Species Human DR4 / TRAIL R1 protein
Length 468
Mass (Da) 50089
Sequence Human DR4 / TRAIL R1 protein sequence
Species
Length
Mass (Da)
Sequence
Species
Length
Mass (Da)
Sequence

DR4 / TRAIL R1 Protein Molecular Weight & PI

Tumor necrosis factor receptor superfamily member 10A precursor (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD261 antigen) Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 24-468 Tumor necrosis factor receptor

Molecular weight (Da)

47835.36

Theoretical pI

6.45

DR4 / TRAIL R1 Protein Structure

Crystal structure of death receptor 4 (DR4; TNFFRSF10A) bound to TRAIL (TNFSF10)
Deposited
2015-07-13   Released:  2017-01-18
Deposition Author(s)
Sheriff, S.
Organism(s)
Homo sapiens
Expression System
Escherichia coli BL21(DE3)
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
3.0000 Å
R-Value Free
0.216
R-Value Work
0.177
5CIR From PDB

Human DR4 / TRAIL R1 protein Secondary structure

DR4 / TRAIL R1 Protein Interaction

Recombinant DR4 / TRAIL R1 Protein Feature

DR4 / TRAIL R1 Protein, Human, Recombinant (His & Fc Tag)

High Purity
> 95 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
High Activity
Measured by its binding ability in a functional ELISA. Immobilized human TNFSF10 at 10 μg/ml (100 μl/well) can bind human TNFRSF10A Fc Chimera with a linear range of 0.625-20 ng/ml.

Recombinant DR4 / TRAIL R1 protein citations

Title
Expression of functional recombinant human fibroblast growth factor 8b and its protective effects on MPP(+)-lesioned PC12 cells
Year
2015
Author
Chen, N;Ma, J;Zhao, Y;Wu, M;Yang, H;Gong, W;Chao, J;Li, X;
Journal
Appl. Microbiol. Biotechnol.
Title
A Novel Fully Human Agonistic Single Chain Fragment Variable Antibody Targeting Death Receptor 5 with Potent Antitumor Activity In Vitro and In Vivo
Year
2017
Author
Lei, G;Xu, M;Xu, Z;Gu, L;Lu, C;Bai, Z;Wang, Y;Zhang, Y;Hu, H;Jiang, Y;Zhao, W;Tan, S;
Journal
Int J Mol Sci
Title
Conjugation to 10 kDa Linear PEG Extends Serum Half-Life and Preserves the Receptor-Binding Ability of mmTRAIL with Minimal Stimulation of PEG-Specific Antibodies.
Year
2017
Author
Nie, Q;Jia, D;Yang, H;Feng, Y;Fan, Q;Shi, Q;Wan, L;Lu, X;
Journal
Mol. Pharm

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