DKK1 cDNA Clone: Expression and Clone Vector / Plasmid

DKK1 cDNA / Gene Overview

DKK1 gene / cDNA is a protein-coding gene which located on 10q21.1. The DKK1 gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, zebrafish, and frog.166 organisms have orthologs with human gene DKK1.

DKK1 cDNA / Gene Function

This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]

DKK1 cDNA / Gene Sequence

LOCUS
LOCUS NM_012242 1913 bp mRNA linear PRI 29-JUL-2018
DEFINITION
Homo sapiens dickkopf WNT signaling pathway inhibitor 1 (DKK1), mRNA.
ACCESSION
NM_012242
VERSION
NM_012242.3

This sequence information is just for reference only.

DKK1 cDNA / Gene Alias

  • DKK-1
  • SK

DKK1 cDNA / Gene Expression

Biased expression in placenta (RPKM 39.1), urinary bladder (RPKM 8.2) and 3 other tissues