Cystatin C cDNA Clone: Expression and Clone Vector / Plasmid

Cystatin C cDNA / Gene Overview

CST3 gene / cDNA is a protein-coding gene which located on 20p11.21. The CST3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog.38 organisms have orthologs with human gene CST3.

Cystatin C cDNA / Gene Function

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Nov 2014]

Cystatin C cDNA / Gene Sequence

LOCUS
LOCUS NM_000099 929 bp mRNA linear PRI 11-JUN-2018
DEFINITION
Homo sapiens cystatin C (CST3), transcript variant 1, mRNA.
ACCESSION
NM_000099
VERSION
NM_000099.3

This sequence information is just for reference only.

Cystatin C Family & Reagents

Gene family

Cystatin C Gene family reagents (Cystatins, type 2)

Approved Symbol Reagent list
CST1
CST4
CST6
CST8
CSTL1
Approved Symbol Reagent list
CST2
CST5
CST7
CST9L
   

Cystatin C cDNA / Gene Expression

Ubiquitous expression in brain (RPKM 148.6), salivary gland (RPKM 118.0) and 25 other tissues